摘要
肺癌是恶性肿瘤发病和死亡的首位原因.近年研究表明,老年肺癌患者衰弱发生率高达42％～86％,而衰弱又会加速肺癌患者疾病进展、影响其放化疗耐受性、增加术后并发症发生率、缩短患者生存期.因此,尽早识别肺癌患者衰弱状态并进行干预对提高肺癌患者预后及生活质量具有重要意义.本文综述了多个肺癌患者衰弱评估工具,包括衰弱表型(FP)量表、G-8老年筛查工具、临床衰弱量表(CFS)、简易体能状况(SPPB)量表、改良衰弱指数(mFI)、FRAIL量表、埃德蒙顿衰弱量表(EFS)、基于实验室检查的衰弱指数(FI-LAB),并指出其优缺点,以期为临床医务工作者早期识别肺癌患者衰弱状态提供参考依据.
Abstract
Lung cancer is the leading cause of cancer morbidity and mortality.Recent studies have shown that the incidence of frailty in elderly patients with lung cancer is as high as 42％-86％,and frailty will accelerate the disease progression of lung cancer patients,affect their tolerance to radiotherapy and chemotherapy,increase the incidence of postoperative complications,and shorten the survival time of patients.Therefore,early identification and intervention of frailty in lung cancer patients is of great significance to improve the prognosis and quality of life of lung cancer patients.This article reviews a number of frailty assessment tools for lung cancer patients,including the Frailty Phenotype(FP)Scale,G-8 Geriatric Screening Tool,Clinical Frailty Scale(CFS),Simple Physical Performance Status(SPPB)Scale,modified Frailty Index(mFI),FRAIL Scale,Edmonton Frailty Scale(EFS),and Frailty Index Based on Laboratory Tests(FI-LAB),and points out their advantages and disadvantages,in order to provide a reference for clinicians to early identify the frailty status of lung cancer patients.
维普
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