Predictive Value of CD64 Index Combined with sTREM-1 for Poor Prognosis of Elderly Patients with Severe Pneumonia
Objective To explore the predictive value of cluster of differentiation 64(CD64)index combined with soluble triggering receptor expressed on myeloid cells 1(sTREM-1)for poor prognosis of elderly patients with severe pneumonia.Methods A total of 122 elderly patients with severe pneumonia admitted to Nantong 3rd People's Hospital from December 2021 to December 2023 were selected.The clinical data of the patients were collected,the patients were divided into poor prognosis group(n=41)and good prognosis group(n=81)according to the prognosis of 90-day follow-up.Multivariate Logistic regression analysis was used to explore the influencing factors of poor prognosis of elderly patients with severe pneumonia.The ROC curve was used to explore the predictive value of CD64 index,sTREM-1 and their combination for poor prognosis of elderly patients with severe pneumonia.Results The age in poor prognosis group was older than that in good prognosis group,proportion of patients with diabetes history,C-reactive protein(CRP),procalctionin(PCT),CD64 index,sTREM-1 were higher than those in good prognosis group,albumin was lower than that in good prognosis group(P<0.05).Multivariate Logistic regression analysis showed that age[OR=1.097,95%CI(1.007-1.195)],diabetes history[OR=8.466,95%CI(1.236-57.979)],CRP[OR=1.345,95%CI(1.125-1.607)],PCT[OR=2.372,95%CI(1.525-3.691)],CD64 index[OR=2.251,95%CI(1.155-4.386)],sTREM-1[OR=1.164,95%CI(1.006-1.346)]were independent influencing factors of poor prognosis of elderly patients with severe pneumonia(P<0.05).ROC curve analysis showed that the AUC of CD64 index,sTREM-1 and their combination for predicting poor prognosis of elderly patients with severe pneumonia was 0.887[95%CI(0.823-0.952)],0.855[95%CI(0.780-0.931)],0.957[95%CI(0.920-0.994)],respectively.The AUC of the combination of the two for predicting poor prognosis of elderly patients with severe pneumonia was larger than the AUC of CD64 index,sTREM-1 for predicting poor prognosis of elderly patients with severe pneumonia(P<0.05),respectively.Conclusion CD64 index and sTREM-1 are independent influencing factors of poor prognosis of elderly patients with severe pneumonia,and their combination has high predictive value for poor prognosis of elderly patients with severe pneumonia.
PneumoniaAgedCluster of differentiation 64Soluble triggering receptor expressed on myeloid cells 1Prognosis
万方数据
维普
