Predictive Value of β2 Microglobulin Combined with Serum Uric Acid for Contrast-Induced Nephropathy after PCI in Patients with Coronary Heart Disease
Objective To explore the predictive value of β2 microglobulin(β2-MG)combined with serum uric acid for contrast-induced nephropathy(CIN)after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods A total of 500 patients with coronary heart disease who underwent PCI in Shijiazhuang People's Hospital from July 2021 to January 2023 were selected.The clinical data of the patients were collected,and the patients were divided into CIN group(n=65)and non-CIN group(n=435)according to the incidence of CIN after PCI.Multivariate Logistic regression analysis was used to explore the influencing factors of CIN after PCI in patients with coronary heart disease.The ROC curve was used to explore the predictive value of the β2-MG,serum uric acid and their combination for CIN after PCI in patients with coronary heart disease.Results The age of the CIN group was older than that of the non-CIN group,β2-MG and serum uric acid in the CIN group were higher than those in the non-CIN group(P<0.05).Multivariate Logistic regression analysis showed that age[OR=2.169,95%CI(1.152-4.085)],β2-MG[OR=4.982,95%CI(2.170-11.437)],serum uric acid[OR=4.236,95%CI(2.015-8.904)]were independent influencing factors for CIN after PCI in patients with coronary heart disease(P<0.05).ROC curve analysis showed that the AUC of β2-MG,serum uric acid and their combination for predicting CIN after PCI in patients with coronary heart disease was 0.766[95%CI(0.727-0.803)],0.768[95%CI(0.729-0.805)],0.853[95%CI(0.819-0.883)],respectively.The AUC of their combination for predicting CIN after PCI in patients with coronary heart disease was greater than AUC of β2-MG,serum uric acid for predicting CIN after PCI in patients with coronary heart disease alone(P<0.05).Conclusion β2-MG and serum uric acid are independent influencing factors for CIN after PCI in patients with coronary heart disease,and their combination has certain predictive value for CIN after PCI in patients with coronary heart disease.
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