Association between Baseline BMI and Its Changes and Cardiovascular Disease Risk Factors in Individuals Aged 40 and Above with Prehypertension
Objective To analyze the association between baseline BMI and its changes and cardiovascular disease risk factors in individuals aged 40 years and above with prehypertension.Methods A total of 8 150 prehypertensive patients aged 40 years and above who underwent physical examination in Emin County,Tacheng area in 2019 were selected as the study objects.Baseline data were collected.BMI<18.5 kg/m2 was considered low body mass,18.5-23.9 kg/m2 was considered normal,24.0-27.9 kg/m2 was considered overweight,and≥28.0 kg/m2 was considered obese.Follow-up data were collected,including cardiovascular disease risk factors and BMI at the end of follow-up.Based on baseline BMI and BMI at the end of follow-up,changes in BMI were divided into four categories:sustained normal(normal body mass at baseline and at the end of follow-up),sustained abnormal(overweight or obese at baseline and at the end of follow-up),reversed normal(overweight or obese at baseline and normal body mass at the end of follow-up),and abnormal outcome(normal body mass at baseline and overweight or obese at the end of follow-up).Cox regression analysis was used to investigate the association of baseline BMI and its changes with cardiovascular disease risk factors.Results Among the 8 150 participants,baseline BMI distribution included:normal in 2 694 cases(33.1%),overweight in 3 195 cases(39.2%),and obese in 2 261 cases(27.7%);BMI change distribution was:sustained normal in 1 880 cases(23.1%),sustained abnormal in 4 201 cases(51.5%),reversed normal in 1 255 cases(15.4%),and abnormal outcome in 814 cases(10.4%).Cox regression analysis showed that overweight and obesity were influencing factors for hypertension,diabetes,and substandard TC,TG,HDL-C,and LDL-C in prehypertensive individuals aged 40 years and above(P<0.05);after adjusting for gender and age,overweight and obesity were still influencing factors for hypertension,diabetes,and substandard TC,TG,HDL-C,and LDL-C in prehypertensive individuals aged 40 years and above(P<0.05).Sustained abnormal was the influencing factor for hypertension,diabetes,and substandard TC,TG,HDL-C,and LDL-C in prehypertensive individuals aged 40 years and above,reversed normal was the influencing factor for hypertension,diabetes,and substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above,abnormal outcome was the influencing factor for substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above(P<0.05);after adjusting for gender and age,sustained abnormal was still the influencing factor for hypertension,diabetes,and substandard TC,TG,HDL-C,and LDL-C in prehypertensive individuals aged 40 years and above,reversed normal was the influencing factor for diabetes,and substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above,abnormal outcome was still the influencing factor for substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above(P<0.05).Conclusion Overweight and obesity are risk factors for hypertension,diabetes,and substandard TC,TG,HDL-C,and LDL-C in prehypertensive individuals aged 40 years and above.Overweight or obesity at baseline and at the end of follow-up are risk factors for hypertension,diabetes,and substandard TC,TG,HDL-C and LDL-C in prehypertensive individuals aged 40 years and above;overweight or obesity at baseline and normal body mass at the end of follow-up are risk factors for diabetes and substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above;normal body mass at baseline and overweight or obesity at the end of follow-up are risk factors for substandard TG,and HDL-C in prehypertensive individuals aged 40 years and above.
PrehypertensionBody mass indexCardiovascular diseasesRisk factors
万方数据
维普
