Effectiveness and Safety of Coronary Intravascular Lithotripsy for Pretreating Severe Coronary Artery Calcification
Objective To investigate the effectiveness and safety of coronary intravascular lithotripsy(IVL)for pretreating severe coronary artery calcification.Methods A total of 85 patients with severe coronary artery calcification who underwent percutaneous coronary intervention(PCI)in the Department of Cardiovascular Medicine,Zhumadian Central Hospital from December 2022 to June 2024 were selected as the study subjects.According to pretreatment methods in PCI,they were divided into the IVL group(n=42)and the non-IVL group(n=43).Surgical indexes,inflammatory indexes(hs-CRP,IL-6,TNF-α)and myocardial zymogram indexes[cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB),myoglobin(Mb)]before operation and at 3 months after operation were compared between the two groups,and the adverse events of the two groups were observed.Results The increase rate of area,stent expansion rate and calcification ring opening rate of lumen at the narrowest part in the IVL group were higher than those in the non-IVL group,surgical time in the IVL group was shorter than that in the non-IVL group(P<0.05).Before operation and at 3 months after operation,there was no significant difference in hs-CRP,IL-6,TNF-α,cTnI,CK-MB,Mb between the two groups(P>0.05).There was no thrombosis or acute vascular occlusion in the two groups,there were 3 cases of vascular dissection in the non-IVL group,with an incidence of 7.0%.Conclusion IVL can improve the increase rate of area,stent expansion rate and calcification ring opening rate of lumen at the narrowest part in the pretreatment of severe coronary artery calcification,which is beneficial to shorten the operation time,and with higher safety.
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