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火绒草中的黄酮苷类成分

Flavoniod glycosides from whole plant of Leontopodium leontopodioides(Wild.)Beauv.

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目的 研究火绒草[Leontopodium leontopodioides(Wild.)Beauv.]中黄酮苷类化学成分.方法 采用反复硅胶柱色谱法、Sephadex LH-20柱色谱法、ODS柱色谱法和反复重结晶等方法进行分离纯化,并通过理化常数测定和波谱分析鉴定了其化学结构.结果 从体积分数为60%的火绒草乙醇溶液提取物中分离得到5个化合物,并鉴定其结构为:芹菜素-7-O-β-D-吡喃葡萄糖苷 (apigenin-7-O-β-D-glu-copyranoside 1)、木犀草素-4'-O-β-D-吡喃葡萄糖苷(1uteolin-4'-O-β-D- glucopyranoside 2)、6-羟基-木犀草素-7-O-β-D-吡喃葡萄糖苷(6-hydroxyluteolin-7-O-β-D-glueo- pyranoside 3)、6-羟基-芹菜素-7-O-β-D-吡喃葡萄糖苷(6-hydroxyapigenin-7-O-β-D-glucopyrano-side 4)、槲皮素-3-为O-β-D-吡喃葡萄糖苷(quercetin-3-O-β-D-glucopyranoside 5).结论 化合物4,5为首次从火绒草属植物中分离得到,化合物2,3为首次从本植物火绒草中分离得到.
Objective To study the flavonoid glycosides from the herbal Leontopodium leontopodioides (Wild.) Beauv. Methods The compounds were isolated by chromatography on silica gel column, Sephadex LH-20 column, ODS column and recrytallization method, and identified on the basis of physico-chemical properties and spectral analysis. Results Five compounds were isolated and identified as apigenin-7-O-β-D-glucopyranoside (1),luteolin-4'-O-β-D-glucopyranoside (2), 6-hydroxyluteolin-7-O-β-D)-glucopyranoside (3),6-hydroxyapigenin-7-O-β-D-glucopyranoside (4), quercetin-3-O-β-D-gluco-pyranoside (5). Conclusions Compounds 4 and 5 are isolated from this genus for the first time, while compounds 2 and 3 are isolated from this herb for the first time.

Leontopodium leontopodioides(Wild. ) Beauv.flavonoid glycosideisolation purietystructural identification

潘春媛、张国刚、米文珍、陈丽娟、王庆、贺杰

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沈阳药科大学中药学院,辽宁沈阳,110016

火绒草 黄酮苷 分离纯化 结构鉴定

2009

沈阳药科大学学报
沈阳药科大学

沈阳药科大学学报

CSTPCDCSCD北大核心
影响因子：0.604
ISSN：1006-2858
年,卷(期)：2009.26(11)
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