首页|高山红景天黄酮类化合物的分离与鉴定

高山红景天黄酮类化合物的分离与鉴定

Separation and identification of flavone compounds from root and rhizome of Rhodiola sachalinensis A.Bor.

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目的 对高山红景天药材的化学成分进行研究.方法 采用反复硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱和半微量制备高效液相色谱分离纯化,根据ESI-MS、'H-NMR和13C-NMR等谱学数据进行结构鉴定.结果 从高山红景天根和根茎的乙醇提取物中分离得到8个单体化合物,分别鉴定为黄酮类化合物herbacctin 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside(1)、三叶豆苷(trifolin,2)、草质素苷(rhodionin,3)、山奈酚(kaempferol,4)、山奈酚7-O-α-L-鼠李糖苷(kaempferol 7-O-α-L-rhamnopyranoside,5)、小麦黄素(tricin,6)和大花红景天素(rhodiolinin,7);另外还得到2(3H)-苯并噻唑硫酮(2(3H)-benzothiazolethione,8).结论 化合物1为新化合物,化合物2和8为首次从景天科植物中分离得到.
Objective To study chemical constituents of root and rhizome of Rhodiola sachalinensis A.Bor.Methods The chemical constituents were isolated by silica, Sephadex LH-20, ODS column chromatography and HPLC.Chemical characters and spectroscopic analysis were employed for the structural identification.Results Eight compounds were obtained and their structures were identified as: herbacetin 3-O-[α-L-rhamnopyranosyl ( 1 → 2 ) -β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside ( 1 ), trifolin ( 2 ), rhodionin ( 3 ),kaempferol ( 4 ), kaempferol 7-O-α-L-rhamnopyranoside ( 5 ), tricin ( 6), rhodiolinin (7) and 2 (3H) -benzothiazolethione ( 8 ).Conclusions Herbacetin 3-O- [α-L-rhamnopyranosyl ( 1→2 ) -β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside(1) is a new flavonol glucoside which has not been reported before.Compounds 2 and 8 are isolated from family Crassulaceae for the first time.

韩颖、金艺淑、于建婷、李军、李玉山

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沈阳药科大学,中药学院,辽宁,沈阳,110016

沈阳医学院,沈洲医院,辽宁,沈阳,110002

高山红景天 黄酮 2(3H)-苯并噻唑硫酮 结构鉴定

2011

沈阳药科大学学报
沈阳药科大学

沈阳药科大学学报

CSTPCDCSCD北大核心
影响因子：0.604
ISSN：1006-2858
年,卷(期)：2011.28(2)
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