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毛樱桃叶化学成分的分离与鉴定

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目的 对毛樱桃(Cerasus tomentosa(Thunb.) Wal1.)叶的化学成分进行研究.方法 采用减压柱色谱、Sephadex LH-20、ODS柱色谱、硅胶柱色谱以及制备高效液相色谱等方法对毛樱桃叶的体积分数为70%的乙醇提取物进行提取分离,根据理化性质及波谱数据鉴定其结构.结果 从毛樱桃叶的体积分数为70%的乙醇提取物中分离得到10个化合物,分别鉴定为(+)-丁香树脂醇[(+)-syringaresinol,1]、(+)-丁香树脂醇-4-O-β-D-吡喃葡萄糖苷[(+)-syringaresinol-4-O-β-D-glucopyranoside,2]、7S,8R-二氢去氢双松柏醇(7S,8R-dihydrodehydrodiconiferyl alcohol,3),7S,8R-5-甲氧基二氢去氢双松柏醇(7S,8R-5-methoxydihydrodehydrodiconiferyl alcohol,4)、山奈酚(kaempferol,5)、槲皮素(quercetin,6)、(-)-表儿茶素[(-)-epicatechin,7)、白蜡树精-6-β-D-半乳糖苷(fraxinol-6-β-D-galactopyranoside,8)、1-(4-羟基-3-甲氧基苯基)-2-[4-(3-羟丙基)-2-甲氧基苯氧基]丙烷-1,3-二醇{1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy] propane-1,3-diol,9}、5,5'二甲氧基-7-氧化落叶松脂醇(5,5'-dimethoxy-7-oxolariciresinol,10).结论 化合物2、4、10为从李属植物中首次分离得到,化合物1、3、8、9为从该植物中首次分离得到.
Isolation and identification of constituents from the leaves of Cerasus tomentosa
Objective To study the chemical constituents of the leaves of Cerasus tomentosa.Methods The chemical constituents of 70% (ψ)ethanol extract of the leaves of Cerasus tomentosa were isolated by various chromatographic techniques including vacuum liquid chromatography,Sephadex LH-20,ODS chromatography column,silica gel column and p-HPLC,and the structures were identified with the help of physicochemical characters and spectroscopic techniques.Results Ten compounds were isolated from 70% ethanolwater extraction and their structures were identified as (+)-syringaresinol (1),(+)-syringaresinol-4-O-β-D-glucopyranoside (2),7S,8R-dihydrodehydrodiconiferyl alcohol (3),7S,8R-5-methoxydihydrodehydrodiconiferyl alcohol(4),kaempferol (5),quercetin (6) (-)-epicatechin (7),fraxinol-6-β-D-galactopyranoside (8),1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy] propane-1,3-diol (9) and 5,5'-dimethoxy-7-oxolariciresinol (10).Conclusions Compounds 2,4 and 10 are firstly isolated from Prunus genus.Compounds 1,3,8 and 9 are isolated from this plant for the first time.

Cerasus tomentosachemical constituentsstructure identification

于丽红、赵伟、黄肖霄、周晨晨、彭缨、宋少江

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沈阳药科大学中药学院,辽宁沈阳110016

沈阳药科大学药学院,辽宁沈阳110016

毛樱桃 化学成分 结构鉴定

2015

沈阳药科大学学报
沈阳药科大学

沈阳药科大学学报

CSTPCDCSCD北大核心
影响因子:0.604
ISSN:1006-2858
年,卷(期):2015.32(4)
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