Optimization of extraction technology for berberine hydrochloride from Phellodendri Chinensis Cortex using ionic liquid by central composite design-response surface methodology
Objective To study the methanol extraction process of berberine hydrochloride of phellodendri chinensis by ultrasonic-ionic liquid collaborative extraction technique.Methods The effect of extraction time, methanol concentration and ionic liquid concentration in the extraction process of berberine hydrochloride from Phellodendri Chinensis Cortex were systematically investigated using ionic liquids [Bmim] [BF4]as the extractant with the ultrasound-assisted extraction technology.Central-Composite response surface design method was used to investigate the extraction rate of extraction time, methanol concentration and ionic liquid concentration.The experimental data were analyzed using second-order polynomial equation and 3D-response surface graphs.Results The optimum extraction conditions were as follows:ultrasound time was 40 min, methanol concentration was 75 ％, and ionic liquid concentration was 1.3 mol· L-1, the extraction rate of berberine hydrochloride of phellodendri chinensis could be up to 5.35％ under this condition.Conclusions The predicted values of the fitted quadratic regression model are well agreed with the experimental values.
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