Preparation of gastric floating microspheres of L.ruthenicum anthocyanins
Objective To prepare floating microspheres of L.ruthenicum anthocyanins by ion gelatin-oven drying method in order to increase the gastric retention time.Methods In this paper,the natural polysaccharide-sodium alginate and chitosan were taken as the main carrier materials and NaHCO3 was used as gas-forming agent.The technology was op tnnized by orthogonal test and the properties were encapsulation efficiency,floating efficiency and in vitro release charateristics.Results The results showed that the optimum preparation parameters were:sodium alginate 47.50 g·L-1,CaC12 40.00 g·L-1,chitosan 3.75 g·L-1,and NaHCO3 15.00 g· L-1.The prepared floating microspheres displayed an excellent drug controlled releasing and could float on simulated fluid for over 12 h.The floating efficiency was 94％.And the encapsulation efficiency was found to be 84.01％.Conclusions The microspheres prepared by this novel method have satisfactory floating ability and encapsulation efficiency with good release properties.Therefore,its preparation technology is an acceptable approach to prepare floating microspheres to obtain gastric retention dosage forms.
NETL
NSTL
万方数据
维普
