Objective To introduce the development of the liver-targeting drug delivery systems modified by glycyrrhetinic acid and provide references for further study and clinical usage of drugs in this field.Methods The liver-targeting drug delivery systems modified by glycyrrhetinic acid are summarized by review the relevant literatures in the recent five years.Results Based on the glycyrrhetinic acid receptors in live target site,nano-scaled drug delivery systems modified by glycyrrhetinic acid (liposomes,nanoparticles and polymeric micelles)and glycyrrhetinic acid-drug complex can effectively deliver the drugs into liver tissues and cells,which further improve the antitumor activity.Conclusions Glycyrrhetinic acid modified livertargeting drug delivery systems have great research values and application prospects.
glycyrrhetinic acidliver targetingliver cancerdrug delivery system
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