沈阳药科大学学报2024,Vol.41Issue(1) :13-24.DOI:10.14066/j.cnki.cn21-1349/r.2023.0329

细胞膜仿生修饰的纳米粒在癌症光疗中的研究进展

Recent advances in cell membrane-coated nanoparticles for cancer phototherapy

李悦 尚靖 夏琪 陈佳 殷佩浩 袁泽婷
沈阳药科大学学报2024,Vol.41Issue(1) :13-24.DOI:10.14066/j.cnki.cn21-1349/r.2023.0329

细胞膜仿生修饰的纳米粒在癌症光疗中的研究进展

Recent advances in cell membrane-coated nanoparticles for cancer phototherapy

李悦 1尚靖 2夏琪 2陈佳 2殷佩浩 1袁泽婷3
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作者信息

  • 1. 上海中医药大学附属普陀医院中心实验室,上海 200062;上海中医药大学中西医结合肿瘤介入研究所,上海 200062
  • 2. 上海中医药大学中西医结合肿瘤介入研究所,上海 200062
  • 3. 上海中医药大学附属普陀医院中心实验室,上海 200062;上海中医药大学中西医结合肿瘤介入研究所,上海 200062;华东理工大学药学院,上海 200237
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摘要

目的 传统的光疗剂容易被免疫系统识别、血液循环快速清除和在肿瘤部位聚集较低等问题进一步降低了光疗疗效.采用细胞膜仿生修饰已成为一种潜在的改善策略,因此,对细胞膜仿生修饰纳米粒在癌症光疗中的应用进行综述.方法 通过查阅近五年的相关文献,对细胞膜修饰纳米粒在癌症光疗中的应用进行分类和总结.结果 不同来源的细胞膜可运用多种制备手段包裹在纳米粒表面,且不会改变其光物理性质.修饰后的纳米粒还赋予了诸多生理学功能,如免疫逃逸、延长体内循环时间、同源靶向等.结论 本文综述了红细胞、肿瘤细胞、干细胞、血小板或巨噬细胞等几种典型细胞膜的优劣势,旨在为细胞膜仿生策略用于癌症光疗中的发展提供新思路.

Abstract

Objective Conventional phototherapeutic agents are easily recognized by the immune system,rapidly cleared by the blood circulation,and low accumulation in the tumor,which further reduce the therapeutic efficacy of phototherapy.Cell membrane coating nanoparticles has emerged as a prospective strategy.Therefore,this review aims to summarize the advances of cell membrane-coated nanoparticles for cancer phototherapy.Methods The application of cell membranes coated nanoparticles in cancer phototherapy was classified and summarized by deeply collecting relevant literature data.Results Membranes from different cell can be coated on the nanoparticles by plenty preparation methods without changing the photophysical properties.The modified nanoparticles are also endowed with many additional physiological functions including immune escape,prolonged circulation time and homologous targeting and so on.Conclusion This review summarizes the advantages and disadvantages of several typical cell membranes such as erythrocytes,cancer cells,stem cells,platelets or macrophages.Therefore,this review will provide new thoughts of the cell membrane-camouflaged nanoparticles in cancer phototherapy.

关键词

细胞膜/光疗/纳米粒/肿瘤

Key words

cell membrane/phototherapy/nanoparticle/tumor

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基金项目

国家自然科学基金资助项目(81973700)

上海市普陀区卫生健康系统科技创新项目(ptkwws202004)

上海中医药大学科技发展基金项目(23KFL084)

出版年

2024
沈阳药科大学学报
沈阳药科大学

沈阳药科大学学报

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影响因子:0.604
ISSN:1006-2858
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参考文献量84
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