Research progress of multi-drug loaded nano-drug delivery systems used to improve the anti-tumor efficacy of docetaxel
Objective To review the mechanism of action of docetaxel co-loaded nano-drug delivery system with other anticancer drugs in tumor therapy,in order to provide certain reference for the study of chemotherapeutic co-loaded nano-drug delivery system represented by docetaxel.Methods"docetaxel","combination therapy","nano-drug delivery system","tumor"and other search terms were used to review the domestic and foreign literature,to summarize the therapeutic effect of docetaxel and other drugs co-loaded nano-drug delivery system on tumor,and to summarize its therapeutic mechanism.Results Docetaxel is a typical taxane antitumor drug.In clinical practice,docetaxel has significant therapeutic effect on various malignant tumors.However,due to its poor tissue specificity,solubility in organic solvents,and drug resistance,the existing docetaxel injection has affected its anti-tumor efficacy to some extent and produced some adverse reactions.Combining other drugs with docetaxel is an effective way to improve the anti-tumor effect of docetaxel,overcome its resistance and reduce its adverse reactions.However,the simple physical mixture of several drugs cannot solve the existing defects of docetaxel.With the help of nano-drug delivery system,the above defects can be effectively overcome.Conclusion In the future,the significance of nano-drug delivery system in the delivery of co-loaded anti-tumor drugs should be explored deeply,and the co-loaded chemotherapy drugs represented by docetaxel should be promoted to make greater progress in the treatment of cancer.
万方数据
维普
