Selection of comprehensive evaluation indexes for efficacy and safety in anti-tumor drug effect research
Objective Body mass,tumor volume,and tumor inhibition rate in traditional anti-tumor evaluation indicators can respectively reflect safety and efficacy of preparation.But a single indicator cannot consider both points.For this reason,a new evaluation index of anti-tumor drug efficacy has been proposed,among which the tumor inhibition index can comprehensively evaluate the efficacy of drug.Methods Taking the pharmacodynamic experiment data of epirubicin-related preparations as an example,we analyzed calculation results of"new"and"old"anti-tumor evaluation indexes.Results Tumor inhibition rate of mice in PEG-modified liposome group(0.80±0.05)was not significantly different from that of sialic acid-modified liposome group(0.89±0.01,P ≥0.05),but tumor inhibition index of mice in PEG-modified liposome group(40±9)was significantly lower than that of sialic acid-modified liposome group(82±7,P＜0.001).Conclusion In this experiment found that"new"anti-tumor evaluation index is more suitable for data analysis of anti-tumor research.
万方数据
维普
