The progress on protein kinase CK2 and its inhibitors in the multi-drug resistance of tumors
Objective Tumor multidrug resistance is one of the main reasons for the failure of clinical chemotherapy.Casein kinase 2(CK2)is a highly conserved serine/threonine protein kinase with a wide range of biological activities,that phosphorylates hundreds of substrates.The activation and over-expression of CK2 play an important role in the tumor genesis,development and drug resistance.In addition,CK2 is involved in drug efflux,DNA damage repair and drug escape responses through a variety of mechanisms and signaling pathways,and regulates the activity of molecular chaperones in drug-resistant cells.In this study,the structure,function of CK2 and its mechanism in multi-drug resistance of tumors are summarized,and the CK2 inhibitors in blood system tumor,breast cancer,gastric cancer,lung cancer and other solid tumors are discussed,which will provide new ideas for the development of new molecular markers of drug resistance and treatment plan for clinical targeted therapy.
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