Research progress of stem cell therapy for rheumatoid arthritis
Objective Rheumatoid arthritis(RA)is an immune disease with complex pathogenesis.Recently,stem cell have become a research hotspot in the treatment of immune diseases because of their strong immune regulation and anti-inflammatory ability.This article reviews the research progress of stem cell therapy in the treatment of RA,which can be used as a reference for follow-up research.Methods The progress of stem cell therapy in the treatment of RA was summarized and analyzed by searching the relevant literatures at home and abroad through the platforms of Pubmed and CNKI.Results Stem cells can effectively resist RA by"immune reset"or suppression of autoimmunity.At present,mesenchymal stem cell and hematopoietic stem cell transplantation can significantly improve the clinical symptoms of RA patients,reduce rheumatoid factor,anti-cyclic citrullinated peptide antibody and C-reactive protein,and reduce disease activity.The treatment process is safe and feasible with no obvious adverse reactions.Conclusion Stem cell therapy is safe and effective,but there are still some limitations,which can be further explored through a large number of clinical trials in the future to bring greater benefits to RA patients.
万方数据
维普
