Objective The drug release mechanism,the application in oral administration and the limiting factors of various oral liquid sustained and controlled release technologies at this stage are reviewed to provide reference for the development of such preparations.Methods Related literatures at home and abroad were reviewed to summarize the oral liquid sustained and controlled release technologies.Results At present,there were some liquid sustained and controlled release preparations based on ion exchange resin and microcapsule technology on the market,furthermore,microspheres,solid lipid nanoparticles,in situ gel and so on were also applied to this area.Conclusion Oral liquid sustained and controlled release drug delivery system is a new generation of sustained and controlled release drug delivery technology.Compared with solid sustained and controlled release preparations,it has good oral acceptability,flexible dose adjustment,and obvious advantages in administration compliance.This preparation technology has good development and application prospects.
关键词
口服液体缓控释给药系统/离子交换树脂/微囊/缓释混悬剂
Key words
Oral liquid sustained and controlled release drug delivery system/ion exchange resin/microcapsule/sustained release suspension
维普
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