Traumatic brain injury(TBI)is a common injury that threatens the safety of human life.Due to its complex injury mechanism,only surgery is used as an emergency treatment method in clinics.However,it lacks the efficient and safe strategies for the prevention and protection of the secondary TBI.The research on TBI mechanism and the search for effective therapeutic drugs to alleviate the pain of patients have become the focus of current research and received extensive attention.This paper reviews the research progress of traumatic brain injury(TBI)in recent years,including injury mechanism,the establishment of animal experimental model and the evaluation index,potential therapeutic drugs and drug delivery systems.The related drug delivery systems summarize the applications of polymer nanoparticles,hydrogels,dendritic polymers,liposomes,micelles and extracellular vesicles as drug carriers in TBI therapy.
关键词
创伤性脑损伤/损伤机制/药物递送系统/动物模型
Key words
traumatic brain injury(TBI)/damage mechanism/drug delivery systems/animal model
维普
万方数据