With the development of medical technology,the co-delivery of drugs and genes has become a popular approach in cancer treatment.Intelligent delivery systems have solved some issues such as carrier off-targeting,cytotoxicity,and the targeting of gene drugs in gene drug delivery.This article reviews the literature on various aspects of intelligent gene drug delivery using keywords such as"gene drugs","intelligent delivery systems","temperature-sensitive","light-sensitive","pH-sensitive","magnetic sensitive",and"redox-sensitive",and summarizes the applications of intelligent delivery systems in gene drug therapy.Through the development of intelligent gene drug delivery systems,it has been possible to achieve a sensitive response to the tumor microenvironment in the body,thereby enabling the timed,quantitative,and targeted intelligent regulation of gene drug release.The delivery systems could provide more strategies for the development of tumor gene drug therapy modalities.
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