Progress research on inhibitors of SARS-CoV-2 RNA dependent RNA Polymerase
Objective The epidemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 has caused a global pandemic,so it is important to find broad-spectrum antiviral drugs.RNA-dependent RNA polymerase of RNA virus is a kind of non-structural protein which is highly conserved in structure and function among different viruses.It is important to develop new small molecular inhibitors targeting this polymerase.In this review,starting from the structure of SARS-CoV-2 RNA-dependent RNA polymerase,we expounded the mechanism of the viral RNA-dependent RNA polymerase and the characteristics of different kinds of inhibitors.The action characteristics and mechanism of nucleoside analogues and non-nucleoside analogues were introduced from the perspective of medicinal chemistry.We reviewed the relationship between the chemical structure and biological activity of many small molecular polymerase inhibitors.
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