Antitumor mechanism and combined therapeutic potential of norcantharidin
Objective To systematically describe the pharmacological mechanism and clinical application of norcantharidin,and to prospect the development of improved drug delivery system of norcantharidin,so as to lay a foundation for further research and clinical application of norcantharidin.Methods Literatures at home and abroad were reviewed,analyzed and summarized.Results Norcantharidin can not only achieve the anti-tumor effect through single drug multi-target mechanism,but also have the function of raising leukocytes and regulate the immune balance of the body;Norcantharidin can be used in combination with chemotherapy drugs,immune drugs,targeted drugs or radiotherapy to achieve synergistic anticancer effect;Norcantharidin is expected to develop new improved systems with high targeting,slow and controlled release and low toxicity and side effects,such as fat emulsion injection,emulsomes and liposome-emulsion hybrid delivery system.Conclusion The clinical application of norcantharidin has a broad prospect and needs further research.
norcantharidinanti-tumormechanism of actionclinical combinationdrug delivery system
NETL
NSTL
万方数据
维普
