Objective To systematically describe the pharmacological mechanism and clinical application of norcantharidin,and to prospect the development of improved drug delivery system of norcantharidin,so as to lay a foundation for further research and clinical application of norcantharidin.Methods Literatures at home and abroad were reviewed,analyzed and summarized.Results Norcantharidin can not only achieve the anti-tumor effect through single drug multi-target mechanism,but also have the function of raising leukocytes and regulate the immune balance of the body;Norcantharidin can be used in combination with chemotherapy drugs,immune drugs,targeted drugs or radiotherapy to achieve synergistic anticancer effect;Norcantharidin is expected to develop new improved systems with high targeting,slow and controlled release and low toxicity and side effects,such as fat emulsion injection,emulsomes and liposome-emulsion hybrid delivery system.Conclusion The clinical application of norcantharidin has a broad prospect and needs further research.
norcantharidinanti-tumormechanism of actionclinical combinationdrug delivery system
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