Research progress of aptamer sensor in the detection of small molecule drugs
Objective To accurately and quantitatively detect small molecule drugs that are prone to residue,various kinds of aptamer sensors have been developed by using the strong specificity and high affinity of aptamers.This article reviews and summarizes the existing aptamer sensors for several types of small molecule drugs,so as to further promote the development and application of aptamer sensors in the detection of small molecule drugs.Methods The literatures on the development of aptamer sensors for various small molecule drugs at home and abroad in recent 20 years were searched.Results The application of aptamer sensors in the detection of small molecule drugs such as fever and pain relief,anesthesia,antibiotics,and hormones was summarized,and their basic principles were overviewed.At the same time,the application prospects of aptamer sensors in analysis and detection were discussed.Conclusion This provides a reference for the further development and application of aptamer sensors in the detection of small molecule drugs.