刺激响应型纳米载药系统用于抗多药耐药肿瘤的研究进展
Research progress of stimulus-responsive nanodrug delivery systems for anti-multidrug resistant tumors
张梦玮 1杨硕晔 1王振威 1徐晴晴 1张璐 1崔兰 1屈凌波2
作者信息
- 1. 河南工业大学 生物工程学院,河南 郑州 450001
- 2. 河南工业大学 生物工程学院,河南 郑州 450001;郑州大学 化学与分子工程学院,河南 郑州 450001
- 折叠
摘要
目的 对新型刺激响应型纳米载药系统(nanodrug delivery systems,NDDS)在抗肿瘤多药耐药(multidrug resistance,MDR)中的应用进行综述.方法 通过查阅近年来国内外相关文献,对各种新型刺激响应型纳米载药系统在抗MDR型肿瘤方面的研究进展进行整理归纳.结果 目前已有多种内源性和外源性刺激响应型及多重响应型纳米载药系统构建成功并应用于抗MDR型肿瘤,取得了良好的疗效.结论 纳米载体具有生物相容性好,可修饰性强,载药量高等优点被广泛用于抗肿瘤药物递送领域.基于正常组织和肿瘤组织微环境的不同生理特性,合理设计开发新型刺激响应型纳米载药系统,可进一步提高药物递送的特异性和有效性,显著提升抗MDR型肿瘤的疗效.为后续的研究和开发提供有益参考.
Abstract
Objective To review the application of novel stimulus-responsive nano drug delivery systems(NDDS)in anti-tumor multidrug resistance(MDR).Methods The research progress of various new stimulus-responsive NDDS in anti-mdr tumor were summarized by referring to the relevant literatures at home and abroad in recent years.Results At present,a variety of endogenous and exogenous stimulus-responsive and multi-responsive NDDS have been successfully established and applied to anti-MDR tumors,and good efficacy has been achieved.Conclusion Nanocarriers have advantages of good biocompatibility,ease of modification and high loading capacity,and have been widely used as anti-tumor drug delivery vehicles.Based on the significant microenvironment difference of physiological properties between normal tissue and tumor tissue,rational design and development of novel stimulus-responsive nanocarrier systems can further improve the specificity and effectiveness of drug delivery,and significantly improve the efficacy of anti-MDR tumors.They can provide useful reference for research and development of efficient NDDS in the future.
关键词
纳米材料/多药耐药/刺激响应型/药物载体/抗肿瘤Key words
nanomaterial/multidrug resistance/stimulus-responsive/drug carrier/anti-tumor引用本文复制引用
基金项目
河南省科技攻关计划(192102310419)
河南省高等学校重点科研项目(21A350003)
河南工业大学青年骨干教师培育计划(21420075)
出版年
2024
NETL
NSTL
维普
万方数据