Research progress of stimulus-responsive nanodrug delivery systems for anti-multidrug resistant tumors
Objective To review the application of novel stimulus-responsive nano drug delivery systems(NDDS)in anti-tumor multidrug resistance(MDR).Methods The research progress of various new stimulus-responsive NDDS in anti-mdr tumor were summarized by referring to the relevant literatures at home and abroad in recent years.Results At present,a variety of endogenous and exogenous stimulus-responsive and multi-responsive NDDS have been successfully established and applied to anti-MDR tumors,and good efficacy has been achieved.Conclusion Nanocarriers have advantages of good biocompatibility,ease of modification and high loading capacity,and have been widely used as anti-tumor drug delivery vehicles.Based on the significant microenvironment difference of physiological properties between normal tissue and tumor tissue,rational design and development of novel stimulus-responsive nanocarrier systems can further improve the specificity and effectiveness of drug delivery,and significantly improve the efficacy of anti-MDR tumors.They can provide useful reference for research and development of efficient NDDS in the future.
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NSTL
万方数据
维普
