Research progress of traditional Chinese medicine affecting atherosclerosis
Objective Atherosclerosis(AS),featured with excess lipid deposited in the arterial wall,is a chronic inflammatory disease with complex onset to treat.In AS,disorders within lipid metabolism,oxidative stress,intestinal flora and its metabolites,non-coding RNA,cell autophagy and apoptosis would bring complex inflammatory environment which might promote the development of the disease.At present,traditional Chinese medicine has shown a better therapeutic advantage for AS treatment.Chinese medicine monomers,extracts and compounds containing polysaccharides,flavonoids,alkaloids,glycosides,lactones,lignans and terpenoids can regulate lipid metabolism,oxidative stress,monocyte adhesion and differentiation,migration as well as the proliferation of various cells,intestinal flora structure and abundance,programmed cell death,miRNA and lncRNA,etc.,and participate in lipid accumulation,endothelial cell injury,monocyte adhesion,foam cell formation,fiber cap formation and plaque rupture of AS.Given the pathogenesis of AS,this paper will focus on the inflammatory action in AS,and detailed in the current research progress of Chinese medicine treating diseases.
atherosclerosisinflammationtraditional Chinese medicine
NETL
NSTL
万方数据
