Advances in the research on the relevance of antibiotics in intestinal diseases
The intestinal microbiota plays an increasingly critical role in the pathogenesis of intestinal diseases,not only by altering the intestinal flora and metabolites,but also by directly or indirectly modulating the immune response in the intestinal environment,ultimately exacerbating intestinal damage.Antibiotics,as mainstream drugs against bacteria that are detrimental to intestinal health,can affect the pathogenesis of intestinal diseases by reducing the concentration of bacteria in the gut,altering the composition of the intestinal microbiota,regulating the production of metabolites,and modulating the immune response.However,there are still many uncertainties in the application of antibiotics for the treatment of intestinal diseases,such as the emergence of multi-drug resistant pathogens,high expression of antibiotic resistance genes,and the occurrence of systemic side effects and complications.This review introduced the relationship between the occurrence of intestinal diseases and intestinal microbiota,described the clinical application of antibiotics in the treatment of intestinal diseases,and systematically summarized the pros and cons of the role of antibiotics in the treatment of intestinal diseases,which provided strong support for the application of antibiotics in intestinal diseases.
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