Research progress on the antibacterial and antifungal activities of sodium houttuyfonate and its analogue
With the frequent use of antibiotics,the situation of bacterial resistance is increasingly severe.Searching for compounds with antibacterial activities from natural products is an effective way to find new antibacterial agents or antibiotic enhancers and deal with the current situation of bacterial resistance.Sodium houttuyfonate,which has antibacterial and antifungal activities,is the adduct of sodium bisulfite and houttuynin,the main antibacterial ingredient of Houttuynia cordata Thunb.Sodium new houttuyfonate is one of the analogues of sodium houttuyfonate.Sodium houttuyfonate can influence gene expression of bacteria and fungi,inhibit biofilm formation,alter cell morphology of bacteria or fungi and is synergistic with some existing antibacterial or antifungal agents.The metabolic kinetics,antibacterial effects,underlying antibacterial mode of mechanisms and toxicological studies of sodium houttuyfonate and its analogue are summarized in this review in order to provide reference for the discovery of new antibacterial agents and antibacterial ehnhancers from traditional Chinese medicine.
sodium houttuyfonatesodium new houttuyfonateantibacterialantifungal
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