Research progress on the application of natural product active ingredient microneedles in the treatment of facial hyperpigmentation
Microneedles are a safe and effective new drug delivery system.It encapsulates the drugs within the matrix material,dissolves the drugs in the dermis layer of the skin through pricking,increases the drug concentration at the administration site,enhances drug absorption,and ultimately produces the desired therapeutic effect.Facial hyperpigmentation is caused by various factors,including the body's self-regulation,physical and chemical factors,which leads to changes in pigmentation on the face,resulting in different colors,ranges,and depths.This condition seriously impacts people's mood and overall sense of well-being.However,the current treatment of chloasma generally has problems such as a lack of significant effect,frequent recurrence,and skin sensitivity.Moreover,it is difficult for the existing therapeutic drugs to penetrate the skin.The combined use of microneedles and drugs can enhance drug absorption and improve drug efficacy,making it a promising approach for treating facial hyperpigmentation.As the functional components of whitening products,natural ingredients have the advantages of being highly safe,limited side effects,and offering high performance cost ratio.As a result,they have garnered widespread attention.However,the transdermal penetration of natural products is typically achieved through the use of ointments,emulsions,gels,etc.,which have the low skin permeability and limited bioavailability.Therefore,the delivery of active ingredients from natural products in the form of microneedles holds great potential for application.This article systematically summarizes the use of microneedles to encapsulate natural product active ingredients.It covers topics such as natural product components,properties of microneedles and anti-pigmentation effects,and the functional design and future development of microneedles containing natural product active ingredients.
万方数据
维普
