Preclinical research progress of asiatic acid in the treatment of diabetes mellitus and its complications
Asiatic acid,the main active ingredient in traditional herbal medicine of Centella asiatica,has significant therapeutic effects in wound healing.In recent years,it has been found that asiatic acid can increase the expressions of antioxidant-related proteins,thereby protecting islet β cells against the damage of oxidative stress and promoting cell proliferation.Additionally,asiatic acid can also ameliorate the oxidative stress of liver tissue addressed in mitochondria,reverse the phenomenon of insulin resistance,and improve the insulin sensitivity of skeletal muscle by upregulating the expressions of insulin reception-related proteins,thus playing the important role in improving glucose homeostasis.Furthermore,asiatic acid has also shown good therapeutic effects on related complications of diabetes such as diabetic nephropathy,diabetic cardiovascular disease and diabetic wound healing.This article summarizes recent progresses in the treatment of diabetes and its complications with the use of asiatic acid,in order to provide a reference for further research on its clinical research and application.
万方数据
维普
