Advances in reactive oxygen species scavenging delivery systems for the treatment of inflammatory bowel disease
Objective Inflammatory bowel disease(IBD)is a chronic non-specific gastrointestinal disorder with an extremely complex aetiology associated with an excessive immune response that leads to the pathological release of reactive oxygen species through tissue injury and chronic inflammation.Targeting accumulated reactive oxygen species is a viable strategy to inhibit inflammatory bowel disease,and accordingly,overexpression of reactive oxygen species can trigger drug release from novel delivery systems to alleviate inflammatory bowel disease symptoms.However,antioxidants for the treatment of inflammatory bowel disease are unstable in the harsh gastrointestinal environment,and in order to overcome this shortcoming,researchers have attempted to construct antioxidant delivery systems as a way to improve the therapeutic effects of antioxidants.The article describes the antioxidants with good reactive oxygen removal capacity,such as enzymes,metals,polyphenols,natural pigments,and nitrogen-containing oxides,in the hope of providing a reliable reference for the development of antioxidant delivery systems.
reactive oxygen speciesinflammatory bowel diseasedrug delivery system
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