Studies on crystallization inhibition effects of polymers on nitrendipine amorphous solid dispersions
Objective To prepare amorphous solid dispersion(ASD)with different polymer carriers by using nitrendipine(NTD)as a model drug,and to evaluate the crystallization inhibition effects of different polymers on NTD ASD.Methods Amorphous NTD was prepared by the melt quenching method and characterized by using the polarizing microscope,the differential scanning calorimeter and the powder X-ray diffractometer.Subsequently,nitrendipine amorphous solid dispersions at a drug loading of 90%(NTD90%-ASD)were prepared by solvent evaporation with three different polymers(PVP,PVP VA and Soluplus),and the physical characterization of THE ASD system was carried out.The crystallization rates of neat amorphous NTD and NTD90%-ASD were studied using a polarizing microscope.Finally,the crystallization rates of each system were calculated.Results The crystallization rate of ASD was significantly lower than that of the neat amorphous NTD.Conclusion Soluplus has the best crystallization inhibition effects on amorphous NTD,followed by PVP VA and PVP.
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