The preparation and pharmacodynamics of resveratrol nanopreparations
Objective To prepare flexible liposomes and liposome gel from resveratrol,and investigate their in vitro characteristics and the therapeutic effect of melasma.Methods Resveratrol was prepared into flexible liposomes and combined with gel to prepare liposome gel.The in vitro release,in vitro transdermal delivery,pharmacodynamics and skin irritation of the two preparations were investigated.Results The obtained resveratrol liposome gel had a particle size of(148.27±2.90)nm and a PDI of(0.132±0.01),which belong to shear thinning non-Newtonian fluid.The in vitro release results showed that the release rate of resveratrol ethanol solution was relatively fast,and the release amount reached 75.99%at 4 h,which reached the release equilibrium.The release amount of resveratrol flexible liposome and liposome gel were 59.99%and 40.30%respectively at 8 h,which could significantly delay the release of the drug and maintain a long release cycle.In vitro transdermal test results showed that the permeability of resveratrol flexible liposome was higher than that of liposome gel,but the retention was lower than that of liposome gel.Both resveratrol flexible liposome and liposome gel had no skin irritation,and could reduce the content of melanin caused by ultraviolet irradiation in skin tissue,which was similar to blank group and significantly lower than that of the modeling group.Conclusions Resveratrol nano-preparation has good retention in the skin,which can not only effectively treat melasma,but also enhance antioxidant capacity and reduce local damage.
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