Pramipexole dihydrochloride is a selective non-ergot-like dopamine receptor agonist,which is generally used in the treatment of Parkinson′ s disease and restless leg syndrome.It has various pharmacological effects,such as anti-depressant,antioxidant,anti-inflammatory,and neural protection.Pramipexole dihydrochloride is rapidly absorbed by oral administration and has high bioavailability.At present,pramipexole dihydrochloride as a single medication has been marketed with common tablets and sustained-release tablets,which are commonly used in clinical practice in combination with other drugs to improve drug safety.In recent years,the dosage form reform of pramipexole dihydrochloride has become the focus of research and development,aiming to improve the efficacy of pramipexole dihydrochloride and reduce adverse reactions.This review gives a comprehensive summary of the researches on physicochemical properties,pharmacological effects,pharmacokinetic characteristics,drug combination and new dosage forms of pramipexole dihydrochloride in recent years,with the aim of providing literatures basis and new ideas for the further development of pramipexole dihydrochloride.
万方数据
维普
