Analysis of therapeutic effect of aripiprazole or risperidone combined with clozapine in the treatment of refractory schizophrenia
Objective:To investigate the therapeutic effect of aripiprazole or risperidone combined with clozapine in the treatment of treatment-refractory schizophrenia(TRS).Method:A retrospective analysis was conducted on the clinical data of 90 patients with TRS who received treatment at Tanggu Anding Hospital from May 2021 to May 2022.According to the drug treatment regimen,patients were divided into clozapine group,aripiprazole+clozapine group,and risperidone+clozapine group,with 30 cases in each group.The positive and negative symptom scale(PANSS)score,clinical efficacy,and total incidence of adverse reactions were compared before and after treatment among the three groups.Results:After treatment,the total scores and subscale scores of PANSS in the three groups decreased compared to before treatment(P＜0.05).And after treatment,the total scores and subscale scores of PANSS in aripiprazole+clozapine group and risperidone+clozapine group were lower than those in clozapine group(P＜0.05)and the scores in aripiprazole+clozapine group were lower than those in risperidone+clozapine group(P＜0.05).After treatment,the total effective rates in aripiprazole+clozapine group and risperidone+ clozapine group were higher than those in clozapine group(P＜0.05)and the total effective rate in aripiprazole+clozapine group was higher than that in risperidone+clozapine group(P＜0.05).The total incidence of adverse reactions in the three groups was similar(P＞0.05).Conclusion:The overall efficacy of aripiprazole combined with clozapine in the treatment of TRS is better than that of risperidone combined with clozapine or clozapine alone,and can be promoted as the preferred treatment plan.
国家科技期刊平台
NSTL
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