Effect of doxofylline combined with simvastatin on the treatment of COPD complicated with bronchial asthma based on Th immune response and respiratory function
Objective:To investigate the efficacy of doxofylline combined with simvastatin in the treatment of chronic obstructive pulmonary disease(COPD)complicated with bronchial asthma,and to analyze its effects on Th immune response,respiratory function and lung function.Methods:A total of 97 patients with COPD combined with bronchial asthma admitted to our hospital from Feb 2021 to Feb 2023 were selected as study subjects,and randomly divided into the control group(48 cases)and the study group(49 cases).The control group received doxofylline treatment and the study group received doxofylline combined with simvastatin treatment.The clinical efficacy,occurrence of adverse reactions,pulmonary function,respiratory function,asthma-related clinical indicators[peripheral blood eosinophils(EOS)count,EOS ratio,and serum total immunoglobulin E(IgE)],and Th1/Th2 cytokines[interleukin-2(IL-2),interferon-γ(IFN-γ),IL-4,and IL-6]levels before and after treatment were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the improvement of lung function and respiratory function in the study group was greater than that in the control group(P<0.05).EOS count,EOS ratio and IgE level in the study group were lower than those in the control group(P<0.05).The serum levels of IL-2 and IFN-γ in the study group were higher than those in the control group(P<0.05),while the serum levels of IL-4 and IL-6 were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Doxofylline combined with simvastatin is effective and safe in the treatment of COPD complicated with bronchial asthma.It can improve lung function and respiratory function and reduce airway hypersensitivity,which may be related to the regulation of Th immune response.