Research progress of microRNAs and autophagy in cervical malignant tumors
Cervical cancer is a common gynecological cancer,which seriously threatens women's health.At present,the treatment of drug resistance and recurrence of cervical cancer is still a difficult problem in clinical practice.Studies have found that the occurrence,development and prognosis of cervical cancers are closely related to autophagy.Autophagy is one of the protective mechanisms of human cells.When the orderly autophagy mechanism is disturbed,it will lead to pathological conditions,such as myocardial ischemia-reperfusion,cancer,neurodegenerative diseases,autoimmune diseases,etc.In addition,recent studies have found that microRNAs(miRNAs)have good clinical significance for the pathogenesis,diagnosis,treatment and prognosis of cervical cancer.MiRNAs can regulate autophagy of cancer cells through signaling pathways,affecting the occurrence,development and prognosis of cancer.This article focuses on the role of miRNAs in regulating autophagy in the occurrence and development of cervical cancer.
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