Objective To analyze the application effect of CT/MRI fusion imaging technology in the precise radiofrequency treatment of primary liver cancer.Methods Sixty-four patients with primary liver cancer treated by precision radiofrequency in our hospital from January 2018 to January 2020 were selected as the research object,and the patients were grouped by random number table method.Each group had 32 patients.The control group was given CT imaging,and the observation group was given CT/MRI fusion imaging.The diagnostic results and related parameters were compared.Results There was no significant difference in the complete radiofrequency ablation(100%)and postoperative complete ablation rate(100%)between the observation group and the control group(94%and 94%,P>0.05).The incidence of intraoperative supplementary ablation in the observation group(19%)was higher than 3%in the control group,and the difference was statistically significant(P<0.05).The 6-month and 1-year survival rates of the observation group were 94%and 94%respectively,which had no significant difference from 88%and 84%of the control group(P>0.05).The 2-year survival rate of the observation group(94%)was higher than 75%of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the PVP index between pre-treatment and post-treatment(P>0.05).After treatment,the indexes of hepatic arterial perfusion(HAP),total hepatic blood flow(TNBF),and hepatic perfusion index(HPI)in the patients were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of CT/MRI fusion imaging technology in the precise radiofrequency treatment of primary liver cancer can not only effectively display the disease,especially the lesions that are difficult to diagnose by conventional ultrasound phenomenon,but also monitor the treatment and tumor development at any time,which has high clinical popularization value.