Objective To analyze the clinical application value of multi-layer spiral CT diagnosis in diagnosing small pulmonary nodules.Methods The clinical data of 210 patients with small pulmonary nodules from April 2018 to May 2022 were retrospectively collected,and all patients underwent multilayer spiral CT scans and were compared with postoperative histopathological diagnostic results to determine diagnostic accuracy,specificity,sensitivity,positive predictive value,negative predictive value,false-negative rate,and false-positive rate.Results Malignancy was pathologically confirmed in 210 patients with small pulmonary nodules in 176 patients,accounting for 83.8%.Three of the patients with histopathological results showing malignancy had false-positive cases,1 case with chronic inflammation diagnosed postoperatively as adenocarcinoma of the lung;five cases with squamous cell carcinoma of the lung diagnosed by biopsy as histoplasmosis.The diagnostic accuracy of multilayer spiral CT examination was 96.2%,sensitivity was 91.2%,and specificity was 97.2%.The diagnostic accuracy,sensitivity,and specificity of histopathology were 100%.The positive predictive and negative predictive values were 98.3%and 91.2%,respectively,and the misdiagnosis and leakage rates of multilayer spiral CT examination were 8.8%(3/34)vs 2.8%(5/176).Conclusion Multilayer spiral CT examinations of small pulmonary nodules can reduce the rate of misdiagnosis and leakage and im-prove the accuracy of diagnosis.