摘要
目的：探讨心理治疗辅助帕罗西汀对产后抑郁患者临床疗效的影响。方法选取2014年2月至2015年4月确诊的产后抑郁症患者68例，随机化分组分为研究组和对照组各34例，均给予帕罗西汀片20 mg／d，晨服，疗程为8周，治疗期间不服用其他抗抑郁药物，且产妇均停止哺乳。研究组在此基础上每星期安排一次心理治疗，时长60 min，疗程为8周。比较两组患者的汉密尔顿抑郁量表（HAMD）、抑郁自评量表（SDS）及焦虑自评量表（SAS）评分。结果经过8周的治疗，研究组产后抑郁的临床有效率（100％）显著高于对照组（88．2％），差异有统计学意义（ P＜0．05）。治疗后2、4、6及8周两组HAMD、SDS及SAS评分均较治疗前明显降低，且研究组焦虑抑郁评分明显低于对照组，差异均有统计学意义（ P＜0．05）。结论心理辅助治疗可以明显提高帕罗西汀治疗产后抑郁症的临床疗效。
Abstract
Objective To investigate the effect of paroxetine combined with psychological adjuvant therapy on clinical efficacy in patients with postpartum depression .Methods We selected 68 patients with postpartum depression during February 2014 to April 2015 .They were randomly divided into research or control group ,34 in each group .The both groups were given paroxetine 20 mg/d in the morning.The treatment course was 8 weeks.No other antidepressant drugs during treatment were given and all mothers stopped breastfeeding.Patients in the research group were given psychological auxiliary therapy ,once a week,and 60 min long per time for 8 weeks .Scores of HAMD ,SDS and SAS were compared between the two groups .Results After 8 weeks of the treatment ,the clinical ef-ficient in the research group was significantly higher than that in the control group ( 100% vs.88.2%, P <0.05 ) .The scores of HAMD,SDS and SAS after 2,4,6 and 8 weeks of treatment were significantly reduced in the both groups when compared to before treat -ment,and the reduction in the research group was more when compared to the control group (P <0.05).Conclusion Psychological adjuvant therapy can significantly improve the clinical efficacy of paroxetine in the treatment of postpartum depression .
基金项目
广东省潮州市科技局科研基金资助项目(潮科2015gY46)
NETL
NSTL
维普
万方数据