The research of IgA nephropathy:current status,problems and solutions
IgA nephropathy is the most common primary glomerulonephritis worldwide and a leading cause of end-stage renal disease.Racial and regional differences and familial aggregation support the role of genetic factors in the pathogenesis of IgA nephropathy,while immune abnormalities and production of glycosylation-deficient IgA1 alsorelated to the pathogenesis of IgA nephropathy.Understanding the aetiology and pathogenesis of IgA nephropathy is important for diagnosing,treating and prognosing IgA nephropathy.The purpose of this review is to systematically summarize the recent advances in the genetic studies,the pathogenesis,the microbes and metabolites,and the targeted drugs in IgA nephropathy.
IgA nephropathyGd-IgA1Genetic studyMicrobes and metabolitesTargeted drugs
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