IgA肾病研究的现状、问题与对策
The research of IgA nephropathy:current status,problems and solutions
李明 1司美君 1蔡凤桃 1余学清1
作者信息
- 1. 广东省人民医院,广东省医学科学院,广东 广州 510080
- 折叠
摘要
IgA肾病是全球范围内最常见的原发性肾小球肾炎,是终末期肾脏病的主要病因之一.种族和地域差异及家族聚集性均提示遗传因素在IgA肾病的发病中起着一定的作用,同时免疫系统异常及糖基化缺失IgA1 的产生也与IgA肾病的发病密切相关.研究IgA肾病的病因及发病机制对IgA肾病的诊断、治疗和预后有重要意义.本文对IgA肾病的遗传学研究、发病机制、微生物及代谢物组学及靶向药物等方面进行了相关的综述.
Abstract
IgA nephropathy is the most common primary glomerulonephritis worldwide and a leading cause of end-stage renal disease.Racial and regional differences and familial aggregation support the role of genetic factors in the pathogenesis of IgA nephropathy,while immune abnormalities and production of glycosylation-deficient IgA1 alsorelated to the pathogenesis of IgA nephropathy.Understanding the aetiology and pathogenesis of IgA nephropathy is important for diagnosing,treating and prognosing IgA nephropathy.The purpose of this review is to systematically summarize the recent advances in the genetic studies,the pathogenesis,the microbes and metabolites,and the targeted drugs in IgA nephropathy.
关键词
IgA肾病/糖基化缺失IgA1/遗传学研究/微生物及代谢物/靶向药物Key words
IgA nephropathy/Gd-IgA1/Genetic study/Microbes and metabolites/Targeted drugs引用本文复制引用
出版年
2024
NETL
NSTL
万方数据