Observation on the efficacy of non-invasive positive pressure ventilation and high-flow nasal oxygen therapy in the treatment of mild respiratory failure in patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To investigate the clinical efficacy of non-invasive positive pressure ventilation(NIPPV)and high-flow nasal cannula oxygen therapy(HFNC)in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods One hundred and twelve patients with AECOPD admitted to our hospital from January 2020 to January 2022 were selected.The patients were divided into a control group and an observation group by using random number table method,56 in each group.Under the basis of conventional treatment,the control group was treated with NIPPV while the observation group was treated with HFNC.The levels of serum potassium,serum sodium,pulmonary ventilation and inflammation-related factors as well as scores of dyspnea,eosinopenia,consolidation,acidemia and atrial fibrillation(DECAF)before and after 1 week of treatment were compared between the two groups.The tracheal intubation rate during treatment was also compared.Results After 1 week of treatment,the levels of serum potassium in the observation group were obviously higher than those in the control group(P<0.05).Total airway resistance(R5),central airway resistance(R20),peripheral airway resistance(R5-R20),levels of procalcitonin(PCT),interleukin-17(IL-17),and soluble myeloid cell expression triggering receptors Body-1(sTREM-1)and DECAF scores in the observation group were lower than those in the control group(all P<0.05).The rate of tracheal intubation during treatment was sig-nificantly lower in the observation group compared to the control group(P<0.05).Conclusions Compared with NIPPV in the treatment of patients with AECOPD,HFNC can improve the pulmonary ventilation function more effectively.It also significantly reduces the levels of inflammation-related factors.Thus,HFNC is a ventilation method with high safety and exact efficacy.
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