Analysis of the correlation between the changes of brain white matter microstructure and blood lipid level and the cognitive function in patients with Parkinson's disease
Objective To explore the correlation between the changes of cerebral white matter microstructure and blood lipids levels and the cognitive function in patients with Parkinson's disease(PD).Methods One hundred and seventy-six patients with PD admitted to our hospital from January 2021 to December 2022 were selected as an observation group.Another 89 healthy people with physical examination were included in a control group.The differences in cerebral white matter microstructure,blood lipids levels and cognitive function were compared between the two groups.The correlation of changes of cerebral white matter microstructure and blood lipids levels with cognitive function in the PD patients was analyzed.Results The FA values in all areas of cerebral white matter in the observation group were lower than those in the control group(P<0.05).The blood lipids indexes were lower in the observation group than those in the control group(P<0.05).Among the 176 patients with PD,there were 59 cases(33.52%)with abnormal cognitive function(abnormal cognitive function group)and 117 cases(66.48%)with normal cognitive function(normal cognitive function group.The Moca scores of PD patients in the abnormal cognitive function group were lower than those in the normal cognitive function group(P<0.05).The FA values in all areas of cerebral white matter were lower in the abnormal cognitive function group than those in the normal cognitive function group(P<0.05).The levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and apolipoprotein A1(ApoA1)in the abnormal cognitive function group were lower than those in the normal cognitive function group(P<0.05).There were no statistical differences in the levels of triglycerides(TG)and apolipoprotein B(ApoB)between the two groups(P>0.05).The FA values in all areas of cerebral white matter and the levels of TC,LDL-C,HDL-C and ApoA1 in PD patients were positively correlated with Moca score(P<0.05).Conclusions The cerebral white matter microstructure is abnormal and blood lipids levels are reduced in patients with PD.The FA values in all areas of cerebral white matter,TC,LDL-C,HDL-C and ApoA1 are correlated with abnormal cognitive function.The results can be used for clinical ref-erence.
Parkinson's diseaseCerebral white matter microstructureBlood lipidsCognitive function
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