The efficacy of gangliosides combined with dual antiplatelet therapy in the treatment of progressive cerebral infarction and its impact on the degree of neurological deficits
Objective To observe the clinical effect of ganglioside combined with aspirin and clopidogrel(dual antiplatelet therapy)in the treatment of progressive cerebral infarction(PCI)and its effect on the neurological function.Methods Ninety-six patients with PCI treated in our hospital were divided into a dual antiplatelet group and a combined group by using random number table method,48 in each group.The dual antiplatelet group was treated with aspirin + clopidogrel and conventional treatment.The combined group was treated with ganglioside + dual antiplatelet therapy + conventional treatment.The short-term clinical efficacy,cerebral nerve function injury,cerebral blood perfusion indexes,neurological function-related factors,levels of D-dimer(D-D)and basic fibroblast growth factor(bFGF)as well as adverse reactions were compared between the two groups.Results The total effective rate of the combined group was higher than that of the dual antiplatelet group(P<0.05).After treatment,the score of National Institutes of Health Stroke Scale(NIHSS),D-D and resistance index(RI)in both groups were reduced when compared with those before treatment(P<0.05).After treatment,the score of Glasgow Coma Scale(GCS),cerebral blood volume(CBV),mean blood flow(Qmean)and levels of amino acid neurotransmitter γ-aminobutyric acid(GABA),brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)and bFGF were enhanced when compared to before treatment(P<0.05).The above indexes in the combined group after treatment were significantly better than those in the dual antiplatelet group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions The combination of ganglioside and clopidogrel + aspirin in the treatment of patients with PCI can promote the recovery of cerebral nerve function injury,improve the cerebral blood flow perfusion,and regulate the neurological function reconstruction factors.It is recommended.
GangliosideAspirinClopidogrelCerebral infarctionNeurological function
NETL
NSTL
万方数据
