Analysis of the correlation between the serum soluble CD276 and the prognosis and tumor immune infiltration in advanced high-grade serous ovarian cancer
Objective To explore the correlation between the serum soluble CD276(sCD276)and the prognosis and tumor immune infiltration in advanced high-grade serous ovarian cancer(HGSOC).Methods From March 2017 to March 2020,73 patients with advanced HGSOC hospitalized in Ziyang First People's Hospital were included in a group A and 80 patients with other types of ovarian cancer hospitalized at the same time were included in a group B.Another 80 healthy people were selected as a healthy population group.Serum sCD276 expression levels in the three groups were detected.The group A was divided into a high expression group(≥451.26 pg/ml)and a low expression group(<451.26 pg/ml)based on the median serum sCD276 expression level.The relationship between changes in serum sCD276 levels and different clinical characteristics in patients with advanced HGSOC was analyzed.The survival curves and Cox proportional risk regression were used to analyze the correlation between serum sCD276 levels and the prognosis of advanced HGSOC.Results The expression levels of serum sCD276 in the group A and B were higher than those in the healthy population group(P<0.05),and the serum sCD276 level of the group A was higher than that of the group B(P<0.05).There was no statistically significant difference in the mean disease-free survival rate between low and high expression of sCD276 in ovarian cancer patients(P>0.05).In the group A,the average disease-free survival rate and overall survival rate of patients with low expression were higher than those of patients with high expression group(P<0.05).The serum sCD276 expression level of patients with disease-free survival time≥12 months was lower than that of patients with disease-free survival time<12 months(P<0.05).There was a statistically significant difference between patients with high expression and patients with low expression of sCD276 in the presence or absence of lymph node metastasis,postoperative residual lesions,CD3+positivity,and FoxP3+positivity in the group A(P<0.05).Multivariate COX proportional risk regression analysis showed that residual lesions after surgery,CD3+ positive,FoxP3+positive,and serum sCD276≥451.26 pg/ml were risk factors for the prognosis of advanced HGSOC patients(P<0.05).Immunohistochemical detection of tumor tissue showed that 59 patients in the group A had positive membrane CD276 expression,while 14 patients had negative membrane CD276 expression.The serum sCD276 expression and FoxP3+positive proportion in patients with positive membrane CD276 were significantly higher than those in patients with negative membrane CD276(P<0.05).Conclusions Serum sCD276 is highly expressed in advanced HGSOC.Its elevated levels and the number of TILs marker FoxP3+T cells are risk factors for recurrence or death in patients with advanced HGSOC.Therefore,it is closely related to patients'prognosis.Serum sCD276,also provides a possibility for immune response monitoring during neoadjuvant chemotherapy in advanced HGSOC.
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