摘要
目的 探讨男性内脏型肥胖患者血清25 羟维生素D[25(OH)D]水平与早期颈动脉粥样硬化的关系.方法选取2021 年1 月至2022 年12 月于自贡市第一人民医院健康管理中心体检的男性内脏型肥胖患者 264 例,根据颈动脉内中膜厚度(CIMT)分为单纯内脏型肥胖组(VO组)150 例及内脏型肥胖合并早期颈动脉粥样硬化组(VO-ECAS组)114 例.根据血25(OH)D的四分位数进行维生素D水平分级,将受检者分为Q1 组[25(OH)D≥24.70 ng/ml]、Q2 组[19.70 ng/ml≤25(OH)D<24.70 ng/ml]、Q3 组[16.10 ng/ml≤25(OH)D<19.70 ng/ml],Q4 组[25(OH)D<16.10 ng/ml]各66 例.收集各受试者年龄、体质指数、血压、血糖、血脂、尿酸、25(OH)D、内脏脂肪面积(VFA)等资料,分析男性内脏型肥胖患者血清 25(OH)D水平与早期颈动脉粥样硬化的相关性.结果 VO-ECAS组血清 25(OH)D水平较VO组明显降低(P<0.05),Q1、Q2、Q3 和Q4 组早期颈动脉粥样硬化患病率分别为24.24%、46.97%、51.52%和 65.15%(P<0.05).Pearson相关分析显示,男性内脏型肥胖者血清25(OH)D与收缩压、空腹血糖、三酰甘油、内脏脂肪面积及体质指数呈负相关(P<0.05).二元Logistic回归分析显示:低水平的25(OH)D是男性内脏型肥胖患者合并早期颈动脉粥样硬化的影响因素(P<0.05).结论 内脏型肥胖合并早期颈动脉粥样硬化的男性患者的血清25(OH)D水平较单纯内脏型肥胖者明显降低,25(OH)D水平的下降是内脏型肥胖男性患者发生早期颈动脉粥样硬化的影响因素.
Abstract
Objective To investigate the relationship between serum 25-hydroxy vitamin D(25(OH)D)levels and early carotid atherosclerosis(ECAS)in male patients with visceral obesity.Methods A total of 264 male patients with visceral obesity at Health Management Center,Zigong First People's Hospital from January 2021 to December 2022 were selected.The patients were divided into a simple visceral obesity group(VO group,n=150)and a visceral obesity combined with ECAS group(VO-ECAS group,n =114)according to the carotid inner-media thickness(CIMT).Vitamin D levels were graded according to the quartiles of blood 25(OH)D,and the subjects were divided into Q1 group(25(OH)D≥24.70 ng/ml),Q2 group(19.70 ng/ml≤25(OH)D<24.70 ng/ml),Q3 group(16.10 ng/ml≤25(OH)D<19.70 ng/ml)and Q4 group(25(OH)D<16.10 ng/ml),66 in each group.Data such as age,body mass index(BMI),blood pressure,blood glucose,blood lipid,uric acid,25(OH)D and visceral fat area(VFA)were collected.The correlation between serum 25(OH)D levels and carotid atherosclerosis in male patients with visceral obesity was analyzed.Results Serum 25(OH)D levels in the VO-ECAS groups was significant lower than that in the VO group(P<0.05).The prevalence rates of ECAS in the Q1,Q2,Q3 and Q4 groups were 24.24%,46.97%,51.52%and 65.15%,respectively(P<0.05).Pearson correlation analysis showed that serum 25(OH)D was negatively correlated with systolic pressure(SBP),fasting blood-glucose(FPG),triglyceride(TG),VFA and BMI in the VO-ECAS group(P<0.05).Logistic regression analysis showed that low levels of 25(OH)D were influencing factors for ECAS in male patients with visceral obesity(P<0.05).Con-clusions Serum 25(OH)D is significantly lower in male patients with visceral obesity combined with carotid atherosclerosis than that in patients with simple visceral obesity.The decrease of 25(OH)D level is an influential factor of ECAS in male patients with visceral obesity.
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