Observation on the clinical efficacy of murine nerve growth factor combined with gamma globulin in the treatment of chronic Guillain-Barré syndrome
Objective To investigate the clinical efficacy of murine Nerve Growth Factor(mNGF)combined with gamma globulin(IVIG)in the treatment of Guillain-Barre syndrome(GBS)and their effects on inflammatory factors and muscle strength scores.Methods Seventy-three GBS patients admitted to our hospital from March 2017 to May 2022 were selected.The patients were divided into an observation group(mNGF combined with IVIG treatment,n = 40)and a control group(IVIG treatment,n = 33)according to treatment methods.The clinical efficacy,inflammatory factors,muscle strength scores and limb function(Hughes scale scores)were compared between the two groups.The incidence of adverse reactions during treatment was recorded.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the serum levels of interleukin 4(IL-4)in the observation group were higher than those in the control group,while the levels of IL-21 and IL-23 in the observation group were lower than those in the control group(P<0.05).After treatment,the muscle strength scores of upper and lower limbs in the observation group were higher than those in the control group(P<0.05).After treatment,the Hughes score of limb function in the observation group was lower than that in the control group(P<0.05).Conclusions The clinical effect of mNGF combined with IVIG in the treatment of chronic GBS is better than that of IVIG alone.The combination of the two can effectively inhibit the expression of related pro-inflammatory factors,and significantly improve the muscle strength and limb function of the patients.
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