Biomimetic organoid chips—Interdisciplinary research on pulmonary fibrosis disease
Pulmonary fibrosis is driven by various fibrotic behaviors such as alveolar epithelial cells,interstitial fibroblasts,macrophages,inflammatory cells,vascular endothelial cells and pericytes in the interstitial unit.Limited by current traditional research techniques,animal models cannot observe and monitor the biological behavior of lung cells in real time.The traditional in vitro cell culture model is far away from the microenvironment of human lung interstitial unit,and does not meet the research needs.The rapid development of biomimetic organoid chip technology makes it possible to simulate"lung interstitial"in vitro and fully study"pulmonary fibrosis".This paper focuses on the development of organoid chips as well as their changes and applications in lung models.Therefore,it would provide a new technical platform and detection ideas for the full study of pulmonary fibrosis.
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