Application of serum G-17,PG and SNCG in the diagnosis of early gastrointestinal cancer and precancerous lesions in elderly patients
Objective To analyze the application value of serum gastrin 17(G-17),pepsinogen I(PG I),pepsinogen II(PG II)and gamma-synuclein(SNCG)in the diagnosis of elderly patients with early gastrointestinal cancer and precancerous lesions.Methods A total of 198 elderly patients with early gastric cancer and precancerous lesions confirmed by endoscopy and pathology were selected.They were divided into an early cancer group and a precancerous lesion group.Meanwhile,50 patients with benign gastric lesions were selected as a benign lesion group.Serum G-17,PG I,PG II and SNCG levels were detected,and correlation analysis was performed.The receiver operating characteristic(ROC)curve analysis was used to analyze the diagnostic efficiency of joint detection of above indicators for early gastric cancer and precancerous lesions.Results Serum levels of G-17,PG II and SNCG in the early cancer group were significantly higher than those in the other two groups(P<0.05),and the levels in the precancerous lesion group were sig-nificantly higher than those in the benign lesion group(P<0.05).Serum PG I level and PG I/PG II in the early cancer group were sig-nificantly lower than those in the other two groups(P<0.05),and the two indicators in the precancerous lesion group were significantly lower than those in the benign lesion group(P<0.05).PG I was negatively correlated with G-17 and SNCG(P<0.05),and G-17 was positively correlated with SNCG(P<0.05).ROC curve analysis showed that the sensitivity,specificity and area under the curve(AUC)of joint detection of the four indicators were 93.4%,96.0%and 0.987,respectively.The AUC was larger than that of G-17,PG I,PG I/PG II or SNCG alone(0.960,0.824,0.810 and 0.961).Conclusions The joint detection of serum G-17,PG I,PG I/PG II and SNCG can achieve high diagnostic efficiency for elderly patients with early gastric cancer and precancerous lesions.
Early gastric cancer in the elderlyPrecancerous lesionGastrin 17PepsinogenGamma-synuclein
NETL
NSTL
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