The effects of subanesthetic dose of esketamine on cognitive function in elderly patients after thoracoscopic wedge lobectomy surgery
Objective To explore the effects of subanesthetic dose of esketamine on the recovery and cognitive function in elderly patients undergoing thoracoscopic wedge lobectomy surgery.Methods One hundred and twenty elderly patients undergoing selective thoracoscopic wedge lobectomy under general anesthesia were selected.The patients were divided into an esketamine group(ES group)and a control group(C group)by using random number table method.The ES group was given 0.1 mg/kg of esketamine before 5 minutes of start of general anesthesia.The C group was given an equal amount of physiological saline.The same intraoperative anesthesia scheme and postoperative analgesia methods were performed in both groups.The general conditions during the surgery of the two groups,the postoperative recovery states such as recovery time,extubation time and directional force recovery time,mini mental state examination(MMSE)at different time periods before and after the operation,and the level of inflammatory factors such as serum interleukin-6(IL-6)and tumor necrosis factor(TNF)-α were compared between the two groups.Results There was no significant difference in the operation time,blood loss,blood pressure and blood oxygen between the two groups(P>0.05).The recovery time of awakening,extubation time and directional force time in the ES group was earlier than that in the C group(P<0.05).After6 hours,1 day and 3 days of extubation,the MMSE scores in both groups were lower than those before operation,while those in the ES group were higher than those in the C group(P<0.05).The serum levels of IL-6 and TNF-α in the ES group were lower than those in the C group(P<0.05).Conclusions Before induction of anesthesia,a single intravenous injection of a subanesthetic dose of esketamine can ef-fectively shorten the postoperative recovery time with less influence on patients'cognitive function.Its safety is high.
EsketamineOld ageCognitive functionThoracoscopic surgery
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