The value of CT derived fractional flow reserve in the treatment of chronic coronary syndromes
Objective To investigate the value of FFRCT in the treatment of chronic coronary syndrome(CCS).Methods One hundred and fifty CCS patients with stable chest pain and planned coronary angiography(ICA)tests were included.They were divided into an ICA group,a FFR group and a FFRCT group by using random number table,50 in each group.The ICA group underwent percutaneous coronary intervention(PCI)based on lesions with stenosis≥70%indicated by coronary angiography.The FFR group underwent PCI based on coronary angiography indicated stenosis≥50%.The FFRCT group underwent PCI based on coronary angiography indicated stenosis≥50%and CTFFR value<0.75.All of patients were followed up for mainly cardiovascular adverse events by visit,telephone or medical record at the 1st,3rd,6th,and 12th month,respectively.Cardiovascular adverse events included major adverse cardiovascular events(MACE),targeted and non-targeted vascular PCI,recurrence of angina and heart failure.Results Compare to the FFR group,the area under the ROC curve for the diagnosis of CCS in the FFRCT group was 0.873(95%CI:0.762-0.984)and the cut-off value was0.82.Compared with the ICA group,the interventional treatments guided by the FFR group and the FFRCT group were statistically reduced(P<0.05),but the number of stents between the FFR group and the FFRCT group was no significant difference(P>0.05).Compared with the ICA group and the FFRR group,cardiovascular adverse events was the lowest in the FFRCT group(P<0.05).Conclusions The sensitivity and specificity of FFRCT diagnosis for CCS are high.FFRCT can significantly reduce the number of stent implants and greatly delay and reduce the incidence of cardiovascular adverse events in patients with CCS.
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