Human gut microbiota has been considered to be one of the important factors regulating host health.It can participate in a number of physiological processes in the body,including immune response,nutrient absorption,energy metabolism,in-flammatory response,oxidative stress and neurological function.With aging,the gut microbiota in the host will change significantly,such as the decrease of microbial biodiversity,the increase of interindividual differences in composition,and the increase of the proportion of pathogenic microorganisms.These phenomena have also been shown to be closely related to the degenerative changes of human bone and muscle tissues.Human bone and muscle tissue play an important role in maintaining physical function and improving the quality of life.Musculoskeletal degenerative diseases are one of the important reasons for the quality of life of middle-aged and elderly people and increase the risk of other chronic diseases.Existing evidence shows that gut microbiota may be a potential therapeutic target for musculoskeletal degenerative diseases due to its modifiable and reshaping characteristics.Based on this,this article reviews the research on the effects of gut microbiota on bone and muscle,so as to provide a reference for further related research in the field and improve human muscle and bone health from the perspective of regulating gut microbiota.
NETL
NSTL
万方数据
